Obtaining movies of molecular movement of proteins through serial femtosecond crystallography

Seeing is believing; thus, it would be much better if we could observe real-time molecular level movement of proteins during catalysis, where, for example, binding of a substrate to an active site leads to molecular cleavage and enzymatic action. But, this feat is not realized until recent advent of serial femtosecond crystallography (SFX).   In … More Obtaining movies of molecular movement of proteins through serial femtosecond crystallography

Citations on preprints

Preprints is a relatively new class of scientific publications that seek to expedite the publication of results and new ideas in an updatable format. Specifically, new versions of the same article could be posted when ready. Thus, the publication format provides a forum for the discussion of new ideas and data, and allows authors to … More Citations on preprints

Adidas new line of running shoes for moderate runners

Adidas Supernova Boost running shoes represent a new line of running shoes for moderate runners. Specifically, its thick layer of Boost foam marks a distinct change in design philosophy relative to older models such as Supernova Glide Boost series, which was primarily designed for high speed running.   From personal usage experience with the Supernova … More Adidas new line of running shoes for moderate runners

Reusing the first stage of a commercial rocket: Economic cost of retrofitting a used rocket

Rockets for satellite launches remain the most important cost item of the launch process of any commercial satellite project, given the single use nature of the rocket. Thus, commercial space launch companies such as SpaceX and Blue Origin have endeavoured to develop reusable rocket systems for reducing the cost of commercial satellite launches, and helping … More Reusing the first stage of a commercial rocket: Economic cost of retrofitting a used rocket

Gaining spatial resolution by arranging radio telescopes in interferometric arrays

Interferometry is the way to go in modern radio astronomy. Why? By arranging multiple small radio telescopes in interferometric arrays, spatial resolution of the entire array of smaller dishes is higher than that of a single radio dish of larger diameter.   More importantly, design of interferometric arrays is critical to improving reception of distant … More Gaining spatial resolution by arranging radio telescopes in interferometric arrays

Gut microbiome changes in sync with food intake pattern

Gut microbiome is the consortium of microorganisms that inhabit the mucous membrane lining the large and small intestines, and is responsible for many body functions such as digestion of food and regulation of overall intestinal health. A recent study reported in the New York Times (Link) reveals that the gut microbiome of a population in … More Gut microbiome changes in sync with food intake pattern

Field deployable DNA sequencers

Since its inception in the 1990s, multiple revolutions have occurred in the field of DNA sequencing, where successive iterations of the technology enabled more reliable and less error prone sequencing of increasingly larger segments of DNA from a variety of sources such as human, bacteria, fungi, viruses etc. Indeed, DNA sequencing technology has revolutionized biology … More Field deployable DNA sequencers

Utility of co-expression analysis

In biology, researchers often seek to understand the factors that underpin a particular cellular process or diseased state. Thus, this line of thinking necessarily result in experiment design that seek to correlate molecular events with cellular processes, which could be readout experimentally, either through microscopy techniques or enzymatic biochemical assays. More generally, co-expression analysis is … More Utility of co-expression analysis

Lipid metabolism and its role in obesity and health

Obese but healthy, thin but suffering from a multitude of disorders including metabolic syndrome. For years, this clinical observation, also known as metabolic healthy obese, has befuddled doctors and medical researchers, and motivated significant amount of research aimed at understanding the aetiology of obesity and its implications in health and disease.   Why would obesity … More Lipid metabolism and its role in obesity and health

What is the value of an electric car to the environment at present: zero emissions or reduction in use of fossil energy?

Electric cars are often portrayed in the media as clean, zero emissions vehicles that tap on the latest innovations in renewable energy technologies. However, are they truly zero emissions vehicles and what is their most important contributions to environmental protection?   With an electric motor that runs on energy derived from the power grid, electric … More What is the value of an electric car to the environment at present: zero emissions or reduction in use of fossil energy?