Degeneracy in protein sequence meant that evolutionary conservation occurred at the structure level

Given the importance of many proteins to the maintenance of cellular processes, the structures of the proteins are highly conserved independent of the sequence information at the amino acid and nucleotide level. This raises an important question in evolutionary biology: the direction in which natural selection exerts its effect in selecting for specific information bits … More Degeneracy in protein sequence meant that evolutionary conservation occurred at the structure level

Architecture of multienzyme complex in action: polyketide synthase

Article in Nature, Vol. 531, 24 March 2016, pp. 533, “Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases”   Summary of article: Various domains of polyketide synthases were crystallized individually or as segments, and the overall structure of the enzyme complex elucidated. While the method used structures of individual subunits to reconstruct the … More Architecture of multienzyme complex in action: polyketide synthase