Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Phosphorylation plays important roles in many aspects of cell biology and intra- and intercellular signaling; for example, serving as markers for epigenetic regulation of gene transcription, and more commonly, as a repository of energy for enzymatic and protein function. But, what determines the selection of specific protein sequence motif as sites for inserting a phosphorus … More Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Transmissible cancer in marine bivalves: Implications for mode of transmission of cancer

With their rapid growth rate and need for nutrition, cancer cells move as they seek new niches for nutrients and space for colony expansion. Thus far, the most well studied invasive mechanism for cancer cells is metastasis, where a cancer cell from a primary tumour migrate, through the bloodstream, to a new site suitable for … More Transmissible cancer in marine bivalves: Implications for mode of transmission of cancer

Combining different experiment and instrument approaches to reconstruct how a protein moves and function

Structural biology is a field in biology research that seeks to understand the role of structure in potentiating function of an enzyme, receptor, or intracellular effector. To do that, it needs to first obtain the structure of the biomolecule of interest through either the gold standard X-ray diffraction technique or the more recent method of … More Combining different experiment and instrument approaches to reconstruct how a protein moves and function