Article in PLoS Pathogens, “How Do Bacteria Know They Are on a Surface and Regulate Their Response to an Adhering State?” Comment: Interesting article describing the phenomenon of bacteria attachment to various surfaces, as well as a theory on how the relative strength of adhesive force between bacteria and surface impact on the phenotype … More Why bacteria attach to surfaces?
Growth in a minimal salts medium signifies that a microbe has a competitive advantage over other microbial species for nutrients and, more importantly, environmental habitats. But, how should one confirm that a microbe could grow in minimal salts medium? Specifically, should the inoculum contain any trace of a rich medium? The answer to the latter … More How to confirm that a microbe could grow in minimal salts medium?
Since its inception in the 1990s, multiple revolutions have occurred in the field of DNA sequencing, where successive iterations of the technology enabled more reliable and less error prone sequencing of increasingly larger segments of DNA from a variety of sources such as human, bacteria, fungi, viruses etc. Indeed, DNA sequencing technology has revolutionized biology … More Field deployable DNA sequencers
In biology, researchers often seek to understand the factors that underpin a particular cellular process or diseased state. Thus, this line of thinking necessarily result in experiment design that seek to correlate molecular events with cellular processes, which could be readout experimentally, either through microscopy techniques or enzymatic biochemical assays. More generally, co-expression analysis is … More Utility of co-expression analysis
Article in Nature, Vol. 531, 24 March 2016, pp. 533, “Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases” Summary of article: Various domains of polyketide synthases were crystallized individually or as segments, and the overall structure of the enzyme complex elucidated. While the method used structures of individual subunits to reconstruct the … More Architecture of multienzyme complex in action: polyketide synthase
Technology feature in Nature, Vol. 545, 25 May 2017, pp.511-514, “The making of a medical microchip” Summary of article: A good overview of the use of microfluidics technology in medical diagnosis and point of care detection of etiological agents. Specifically, polydimethylsiloxane (PDMS) based microfluidics technology was featured and its use in many areas of … More Microfluidics in biomedical science technology feature