Field deployable DNA sequencers

Since its inception in the 1990s, multiple revolutions have occurred in the field of DNA sequencing, where successive iterations of the technology enabled more reliable and less error prone sequencing of increasingly larger segments of DNA from a variety of sources such as human, bacteria, fungi, viruses etc. Indeed, DNA sequencing technology has revolutionized biology … More Field deployable DNA sequencers

Utility of co-expression analysis

In biology, researchers often seek to understand the factors that underpin a particular cellular process or diseased state. Thus, this line of thinking necessarily result in experiment design that seek to correlate molecular events with cellular processes, which could be readout experimentally, either through microscopy techniques or enzymatic biochemical assays. More generally, co-expression analysis is … More Utility of co-expression analysis

Architecture of multienzyme complex in action: polyketide synthase

Article in Nature, Vol. 531, 24 March 2016, pp. 533, “Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases”   Summary of article: Various domains of polyketide synthases were crystallized individually or as segments, and the overall structure of the enzyme complex elucidated. While the method used structures of individual subunits to reconstruct the … More Architecture of multienzyme complex in action: polyketide synthase

Microfluidics in biomedical science technology feature

Technology feature in Nature, Vol. 545, 25 May 2017, pp.511-514, “The making of a medical microchip”   Summary of article: A good overview of the use of microfluidics technology in medical diagnosis and point of care detection of etiological agents. Specifically, polydimethylsiloxane (PDMS) based microfluidics technology was featured and its use in many areas of … More Microfluidics in biomedical science technology feature