Role of activating mutation in potentiating cancer

Article in Nature, Vol. 539, 10 November 2016, pp. 304, “Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment”   Summary of article: Effect of the postulated activating mutation, Ptpn11, on leukaemia was investigated in genetically altered mice harbouring the mutation.   Link to the original article: https://www.ncbi.nlm.nih.gov/pubmed/27783593   Category: cancer, biochemistry, developmental … More Role of activating mutation in potentiating cancer

Single cell RNA sequencing for understanding the lineage of cancer cells

Article in Nature, Vol. 539, 10 November 2016, pp. 309, “Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma”   Summary of article: Single cell RNA sequencing of cancer cells from human oligodendroglioma reveals hierarchical development pathway in the cancer; thereby, opening up the technique for use in profiling the developmental pathway and lineage traversed … More Single cell RNA sequencing for understanding the lineage of cancer cells

Standardization of nomenclature in cell biology and biological sciences

The fields of cell biology and biological sciences is awashed with difficult to remember names and abbreviations that do not identify the function of the proteins or their subunits. For example, the FEAR network in the field of cell biology. Thus, I was wondering if some form of standardization could be instituted by the leading … More Standardization of nomenclature in cell biology and biological sciences

Macrophages as delineators of stripe patterns in zebrafish

Perspective article in Science, Vol. 355, Issue 6331, pp. 1258-1259, “Macrophage, a long-distance middlemen”   Summary of article: Macrophages are immune cells that profile for foreign viruses and cells that invade a multicellular organism, but its myriad characteristics and roles in cellular genesis and developmental biology is only beginning to be understood at both a … More Macrophages as delineators of stripe patterns in zebrafish