Description
Constituents of the ribosome, ribosomal proteins play important structural and many as-yet unknown functional roles in the ribosome. Hence, they collectively represent a rich field of study both at the individual and ensemble level. Questions such as the evolution of ribosomal protein, co-evolution of ribosomal proteins and between ribosomal protein and ribosomal RNA would challenge our understanding of these biomolecules that likely arise in early genesis of life on Earth. As such, ribosomal proteins may be living chronicle of evolution of life on Earth, albeit probing at a different facet of the same question compared to 16S rRNA and 18S rRNA. It is with this hindsight and an emerging collection of evidence that posits ribosomal proteins could hold phylogenetic significance. One way to utilize this approach at the aggregate level is through using species-specific ribosomal protein mass fingerprint for microbial identification.
This database hopes to move research along in the field of ribosomal protein biology, evolution, and microbial identification. Each ribosomal protein database in this collection is generated using annotated proteome data for each respective species. Besides extraction of protein name and amino acid sequence, the database of all ribosomal proteins in each species is also augmented with calculated variables such as number of residues, molecular weight, and nucleotide sequence of each ribosomal protein in the large and small subunit of the ribosome. Together, the data presented should find use in a variety of fields ranging from understanding evolutionary biology of ribosomal proteins to determining novel functions of poorly understood ribosomal protein, and using ribosomal protein mass fingerprint for microbial identification through mass spectrometry analysis of the ensemble of ribosomal proteins of each species.
Bacteria
Carnobacterium maltaromaticum LMA 28
Staphylococcus aureus Newman strain
Archaea
Eukaryotes
Looking at life with a scientific lens 