The arduous process of drug discovery and development

Drug development is a continuous process. Specifically, there will always be drugs in preclinical development and more advanced ones in clinical trials. These medicines are typically exorbitant in cost due to a variety of reasons, the most important of which is their small production volume coupled with the need to recoup the hefty investment needed … More The arduous process of drug discovery and development

Elucidating molecular processes of molecules in dilute solutions with X-ray free electron laser spectroscopy

With diffraction quality crystals a rarity and some compounds and proteins almost impossible to crystallize, or in a crystal form without ligand in binding cavity, structural biology is often thought of as a field for the most patient. Why? Notwithstanding whether a particular target protein would form crystals of quality sufficient for structural elucidation, some … More Elucidating molecular processes of molecules in dilute solutions with X-ray free electron laser spectroscopy

Combining different experiment and instrument approaches to reconstruct how a protein moves and function

Structural biology is a field in biology research that seeks to understand the role of structure in potentiating function of an enzyme, receptor, or intracellular effector. To do that, it needs to first obtain the structure of the biomolecule of interest through either the gold standard X-ray diffraction technique or the more recent method of … More Combining different experiment and instrument approaches to reconstruct how a protein moves and function