Inability to predict cancer risk through mathematical modelling

Perspective article in Science, Vol. 355, Issue 6331, pp. 1266-1267, “Genes, environment, and “bad luck”   Summary of article: Multiple papers have used mathematical modelling to simulate cancer risk profile at the population level with varying success. Specifically, attempts have been made in correlating cancer stem cell division number with cancer risk; however, can we … More Inability to predict cancer risk through mathematical modelling

Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Phosphorylation plays important roles in many aspects of cell biology and intra- and intercellular signaling; for example, serving as markers for epigenetic regulation of gene transcription, and more commonly, as a repository of energy for enzymatic and protein function. But, what determines the selection of specific protein sequence motif as sites for inserting a phosphorus … More Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Ethanol pretreatment and bile acid germinants help recover significant number of spore forming gut bacteria previously unculturable

Microbes are the dominant forms of life on Earth both in numbers (6 x 1030) and species. By mediating diverse biogeochemical processes ranging from photosynthesis to leaching of metals from minerals and methane biogenesis, they are essential to the proper functioning of the planet. Nevertheless, most of the microorganisms could not be cultivated in the … More Ethanol pretreatment and bile acid germinants help recover significant number of spore forming gut bacteria previously unculturable