The arduous process of drug discovery and development

Drug development is a continuous process. Specifically, there will always be drugs in preclinical development and more advanced ones in clinical trials. These medicines are typically exorbitant in cost due to a variety of reasons, the most important of which is their small production volume coupled with the need to recoup the hefty investment needed … More The arduous process of drug discovery and development

Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Phosphorylation plays important roles in many aspects of cell biology and intra- and intercellular signaling; for example, serving as markers for epigenetic regulation of gene transcription, and more commonly, as a repository of energy for enzymatic and protein function. But, what determines the selection of specific protein sequence motif as sites for inserting a phosphorus … More Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Collection of microbes in the gastrointestinal tract changes with the diet we eat

Microbes are all around us; in the air we breathe and surfaces we touch. But, we don’t fall sick from exposure to microbes. Why? Because our bodies possess an immune system capable of defending against harmful microbes when we are healthy. More importantly, many of the microbes we are exposed to are harmless, and maybe … More Collection of microbes in the gastrointestinal tract changes with the diet we eat

Transmissible cancer in marine bivalves: Implications for mode of transmission of cancer

With their rapid growth rate and need for nutrition, cancer cells move as they seek new niches for nutrients and space for colony expansion. Thus far, the most well studied invasive mechanism for cancer cells is metastasis, where a cancer cell from a primary tumour migrate, through the bloodstream, to a new site suitable for … More Transmissible cancer in marine bivalves: Implications for mode of transmission of cancer

Elucidating molecular processes of molecules in dilute solutions with X-ray free electron laser spectroscopy

With diffraction quality crystals a rarity and some compounds and proteins almost impossible to crystallize, or in a crystal form without ligand in binding cavity, structural biology is often thought of as a field for the most patient. Why? Notwithstanding whether a particular target protein would form crystals of quality sufficient for structural elucidation, some … More Elucidating molecular processes of molecules in dilute solutions with X-ray free electron laser spectroscopy

Combining different experiment and instrument approaches to reconstruct how a protein moves and function

Structural biology is a field in biology research that seeks to understand the role of structure in potentiating function of an enzyme, receptor, or intracellular effector. To do that, it needs to first obtain the structure of the biomolecule of interest through either the gold standard X-ray diffraction technique or the more recent method of … More Combining different experiment and instrument approaches to reconstruct how a protein moves and function