Category: mechanobiology

T-cell receptor able to use force for sensing different antigens

May 3, 2021

Molecular recognition typically relies on shape of molecules. Specifically, the mechanism guiding molecular recognition require shape-dependent docking of target molecule into a receptor followed by an effector step where conformational change in the receptor result in a signal or action exerted on downstream pathways. In this mode of operation, only molecules of desired shape would … More T-cell receptor able to use force for sensing different antigens

T cell receptors could differentiate between self and non-self antigens through mechanosensing

November 30, 2020

Molecular shape and how well an antigen binds to the binding pocket of a receptor is traditionally how molecular recognition is visualized. However, new research in mechanosensing and mechanobiology has elucidated new evidence indicating that T-cell receptor could differentiate between self and non-self antigens through sensing differences in mechanical force actuated during binding of antigen … More T cell receptors could differentiate between self and non-self antigens through mechanosensing