Utility of molecular simulation in constraining possible mechanisms of macroscopic phenomenon

Molecular mechanisms underpin macroscopic phenomenon that we observe, but inability to visualize microscopic events for determining the mechanisms involved precluded scientists from pinpointing the exact mechanistic details of a phenomenon. However, contemporary molecular simulation tools and techniques such as molecular dynamics have attained the temporal and spatial resolution for informing possible mechanistic details of events … More Utility of molecular simulation in constraining possible mechanisms of macroscopic phenomenon

Understanding the evolutionary dynamics of phosphorylation with fungal species as model system

Phosphorylation plays important roles in many aspects of cell biology and intra- and intercellular signaling; for example, serving as markers for epigenetic regulation of gene transcription, and more commonly, as a repository of energy for enzymatic and protein function. But, what determines the selection of specific protein sequence motif as sites for inserting a phosphorus … More Understanding the evolutionary dynamics of phosphorylation with fungal species as model system